61 Antibiotic Resistant Patterns of Bacterial Pathogens Causing Invasive Neonatal Infections in Northern Alberta

Abstract Background Antimicrobial resistance is one of the most serious global health threats facing world today. The neonatal intensive care unit (NICU) a clinical environment that houses newborn infants who are highly susceptible to overwhelming infection. Early and decisive treatment with powerful anti-microbials tends be preferred choice for treating sick empirically. Prolonged exposure antimicrobials can result in multi-drug resistant organisms (MDROs), which associated mortality due an increase virulence, delay appropriate treatment, lack options. An updated antibiogram important determining optimal empirical antimicrobial sepsis evaluations. There currently susceptibility data bacterial pathogens Northern Alberta region. Objectives objective this study understand antibiotic patterns among isolates responsible bacteremia meningitis NICUs through standard antibiograms produced by microbiology laboratories. Design/Methods We conducted retrospective analyze found during 2013-2021 Alberta. Bacteria isolated from blood cerebrospinal fluid according commonly used antibiotics were collated create provincial antibiogram. Results A total 5562 included frequently Escherichia coli (1521), Staphylococcus aureus (1157), members coagulase-negative staphylococcus (534), Enterococcus faecalis (326), Klebsiella pneumoniae (357) populations. Among 1157 S. isolates, 24% oxacillin (i.e., “methicillin-resistant aureus” or MRSA) 1% vancomycin “vancomycin-resistant VRSA). Of 326 strains spp., there no vancomycin-resistant enterococci (VRE) identified. gram-negative 251 out 2690 (9.6%) producing extended-spectrum beta-lactamase (ESBL), 52% 94% gentamicin amikacin respectively. non-ESBL-producing E. (1521) K. (357), 7% gentamicin. Conclusion useful tool best inform clinicians on agent based identified invasive infections within Our findings these aid next steps developing stewardship program.